Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigm.
Identifieur interne : 000D41 ( Main/Exploration ); précédent : 000D40; suivant : 000D42Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigm.
Auteurs : James M. Shine [Australie] ; Glenda H. Halliday ; Mayra Carlos ; Sharon L. Naismith ; Simon J G. LewisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Attention (physiology), Case-Control Studies, Female, Hallucinations (diagnosis), Hallucinations (etiology), Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Perceptual Disorders (diagnosis), Perceptual Disorders (etiology), Psychiatric Status Rating Scales, Self Report, Visual Perception (physiology).
- MESH :
- complications : Parkinson Disease.
- diagnosis : Hallucinations, Perceptual Disorders.
- etiology : Hallucinations, Perceptual Disorders.
- physiology : Attention, Visual Perception.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Self Report.
Abstract
Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.
DOI: 10.1002/mds.24900
PubMed: 22488861
Affiliations:
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Halliday</name></author><author><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J G" last="Lewis">Simon J G. Lewis</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24900</idno><idno type="RBID">pubmed:22488861</idno><idno type="pmid">22488861</idno><idno type="wicri:Area/PubMed/Corpus">000E19</idno><idno type="wicri:Area/PubMed/Curation">000E19</idno><idno type="wicri:Area/PubMed/Checkpoint">000D73</idno><idno type="wicri:Area/Ncbi/Merge">003611</idno><idno type="wicri:Area/Ncbi/Curation">003611</idno><idno type="wicri:Area/Ncbi/Checkpoint">003611</idno><idno type="wicri:Area/Main/Merge">000D65</idno><idno type="wicri:Area/Main/Curation">000D41</idno><idno type="wicri:Area/Main/Exploration">000D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Investigating visual misperceptions in Parkinson's disease: a novel behavioral paradigm.</title><author><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M" last="Shine">James M. Shine</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Parkinson's Disease Clinic, Brain and Mind Research Institute, The University of Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Halliday, Glenda H" sort="Halliday, Glenda H" uniqKey="Halliday G" first="Glenda H" last="Halliday">Glenda H. Halliday</name></author><author><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name></author><author><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name></author><author><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J G" last="Lewis">Simon J G. Lewis</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Attention (physiology)</term><term>Case-Control Studies</term><term>Female</term><term>Hallucinations (diagnosis)</term><term>Hallucinations (etiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Perceptual Disorders (diagnosis)</term><term>Perceptual Disorders (etiology)</term><term>Psychiatric Status Rating Scales</term><term>Self Report</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hallucinations</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hallucinations</term><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Attention</term><term>Visual Perception</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term><term>Self Report</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Visual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of "single" and "hidden" monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age-matched controls performed the BPP. Using an error score value derived from the control group, 23 patients were identified as having significant deficits on the task. Compared to patients who were unimpaired on the task, this group of patients had significantly higher levels of self-reported hallucinations on the SCales for Outcomes in PArkinson's Disease-Psychiatric Complications and also symptoms of rapid eye movement sleep behavior disorder (RBD). Furthermore, impairment on the BPP was associated with significantly reduced performance on an attentional set-shifting task. Patients with impaired performance on the BPP had higher rates of hallucinations, increased symptoms of RBD, and poorer performance on set shifting, suggesting disrupted processing within the attentional control networks. We propose that the BPP may offer a novel approach for exploring the neural correlates underlying visual hallucinations and misperceptions in PD.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Carlos, Mayra" sort="Carlos, Mayra" uniqKey="Carlos M" first="Mayra" last="Carlos">Mayra Carlos</name><name sortKey="Halliday, Glenda H" sort="Halliday, Glenda H" uniqKey="Halliday G" first="Glenda H" last="Halliday">Glenda H. Halliday</name><name sortKey="Lewis, Simon J G" sort="Lewis, Simon J G" uniqKey="Lewis S" first="Simon J G" last="Lewis">Simon J G. Lewis</name><name sortKey="Naismith, Sharon L" sort="Naismith, Sharon L" uniqKey="Naismith S" first="Sharon L" last="Naismith">Sharon L. Naismith</name></noCountry><country name="Australie"><noRegion><name sortKey="Shine, James M" sort="Shine, James M" uniqKey="Shine J" first="James M" last="Shine">James M. 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